Protective effect of curcumin on immune system and body weight gain on rats intoxicated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)

ÇİFTÇİ O. , TANYILDIZI S., Godekmerdan A.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, cilt.32, ss.99-104, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32 Konu: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3109/08923970903164318
  • Sayfa Sayıları: ss.99-104


Material and methods: For this purpose, 128 3-4-month-old Wistar albino rats with 280-310 g body weights were used. The 2 mu g/kg dose of 2,3,7,8-TCDD and 100 mg/kg dose of curcumin were dissolved in corn oil and orally given to the rats found in the experimental and control groups. Then, the serum samples were taken from all rats at 15, 30, 45 and 60 days to analyzed for the determination of TNF-alpha, IFN-gamma, IL-12 and IL-13 levels by ELISA method. The data of body weight gain was measured at 15, 30, 45 and 60 days.