New coumarin derivatives as carbonic anhydrase inhibitors

Karataş M. O., Alıcı B., Çakır Ü., Cetinkaya E., Demir D., Ergün A., ...More

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, vol.42, no.3, pp.192-198, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 3
  • Publication Date: 2014
  • Doi Number: 10.3109/21691401.2013.794352
  • Journal Name: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.192-198
  • Keywords: benzimidazolium, carbonic anhydrase, coumarin, imidazolium, inhibition, AROMATIC/HETEROCYCLIC SULFONAMIDES, THERAPEUTIC APPLICATIONS, ERYTHROCYTE, TARGET, IX, PURIFICATION, BINDING, CLONING, PHENOL, SITE
  • Inonu University Affiliated: Yes

Abstract

In the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition effects of the derivatives on human carbonic anhydrases (hCA I and hCA II) were investigated as in vitro. Structures of these coumarins were confirmed by FT-IR, (1)H NMR, (13)C NMR and LC-MS analyses. Structure activity relationship study showed that 3d (IC50: 79 mu m M for hCA I and 88 m M for hCA II) performed higher inhibitory activity than others.