Chromium picolinate and chromium histidinate protects against renal dysfunction by modulation of NF-kappa B pathway in high-fat diet fed and Streptozotocin-induced diabetic rats

Selcuk, Mustafa; Aygen, Bilge; Dogukan, Ayhan; Tuzcu, Zeynep; Akdemir, FATİH; KOMOROWSKI, James; ATALAY, Mustafa; Sahin, Kazim

doi:10.1186/1743-7075-9-30

Chromium picolinate and chromium histidinate protects against renal dysfunction by modulation of NF-kappa B pathway in high-fat diet fed and Streptozotocin-induced diabetic rats

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Selcuk M. Y., Aygen B., Dogukan A., Tuzcu Z., Akdemir F., KOMOROWSKI J. R., ...More

NUTRITION & METABOLISM, vol.9, 2012 (SCI-Expanded)

Publication Type: Article / Article
Volume: 9
Publication Date: 2012
Doi Number: 10.1186/1743-7075-9-30
Journal Name: NUTRITION & METABOLISM
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Inonu University Affiliated: Yes

Abstract

Background: Diabetic nephropathy is one of major complications of diabetes mellitus. Although chromium is an essential element for carbohydrate and lipid metabolism, its effects on diabetic nephropathy are not well understood. The present study was conducted to investigate the effects of chromium picolinate (CrPic) and chromium histidinate (CrHis) on nuclear factor-kappa B (NF-kappa B) and nuclear factor-E2-related factor-2 (Nrf2) pathway in the rat kidney.