Chromium picolinate and chromium histidinate protects against renal dysfunction by modulation of NF-kappa B pathway in high-fat diet fed and Streptozotocin-induced diabetic rats

Selcuk, Mustafa; Aygen, Bilge; Dogukan, Ayhan; Tuzcu, Zeynep; Akdemir, FATİH; KOMOROWSKI, James; ATALAY, Mustafa; Sahin, Kazim

doi:10.1186/1743-7075-9-30

Chromium picolinate and chromium histidinate protects against renal dysfunction by modulation of NF-kappa B pathway in high-fat diet fed and Streptozotocin-induced diabetic rats

Selcuk M. Y., Aygen B., Dogukan A., Tuzcu Z., Akdemir F., KOMOROWSKI J. R., ...Daha Fazla

NUTRITION & METABOLISM, cilt.9, 2012 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 9
Basım Tarihi: 2012
Doi Numarası: 10.1186/1743-7075-9-30
Dergi Adı: NUTRITION & METABOLISM
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
İnönü Üniversitesi Adresli: Evet

Özet

Background: Diabetic nephropathy is one of major complications of diabetes mellitus. Although chromium is an essential element for carbohydrate and lipid metabolism, its effects on diabetic nephropathy are not well understood. The present study was conducted to investigate the effects of chromium picolinate (CrPic) and chromium histidinate (CrHis) on nuclear factor-kappa B (NF-kappa B) and nuclear factor-E2-related factor-2 (Nrf2) pathway in the rat kidney.