The effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in comparison with alpha-tocopherol in rat kidneys

Irmak M., Koltuksuz U., Kutlu N., Yagmurca M., Ozyurt H., Karaman A., ...More

UROLOGICAL RESEARCH, vol.29, no.3, pp.190-193, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 3
  • Publication Date: 2001
  • Doi Number: 10.1007/s002400100185
  • Journal Name: UROLOGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.190-193
  • Inonu University Affiliated: No

Abstract

Oxygen-derived free radicals have been implicated in the pathogenesis of renal injury after ischemia-reperfusion. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, exhibits antioxidant and anti-inflammatory properties. To determine whether CAPE offers any advantage over alpha -tocopherol, we compared their effects on an in vivo model of renal ischemia-reperfusion injury in rats. CAFE at 10 mu mol/kg or alpha -tocopherol at 10 mg/kg was administered intraperitoneally before reperfusion. Acute administration of CAFE suppressed ischemia-reperfusion induced renal lipid peroxidation and tissue injury more than alpha -tocopherol. CAFE may therefore offer a therapeutic advantage in acute injury settings.