EGFR blocker lapatinib inhibits the synthesis of matrix metalloproteinases from synovial fibroblasts

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KEHRİBAR D. Y., Emmungil H., BAŞAK TÜRKMEN N., ÇİFTÇİ O., ŞALVA E., Ozgen M.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.52, sa.4, ss.1355-1361, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.55730/1300-0144.5442
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1355-1361
  • Anahtar Kelimeler: Epidermal growth factor, lapatinib, matrix metalloproteinase, rheumatoid arthritis, synovial fibroblast, RHEUMATOID-ARTHRITIS, ANGIOGENESIS, CELLS, DESTRUCTION, TARGET, MODEL
  • İnönü Üniversitesi Adresli: Evet

Özet

Background/aim: Epidermal growth factor receptor (EGFR) family members and their associated ligands may be related to bone and joint destruction in rheumatoid arthritis. Matrix metalloproteinases are responsible for joint and bone tissue degradation. This study is intended to investigate the effect of epidermal growth factor receptor inhibition by lapatinib on the synthesis of matrix metalloproteinases in in vitro.