Three novel mutations in the apolipoprotein E gene in a sample of individuals with type 2 diabetes mellitus

STEPHENS J., Sozen M. M., WHITTALL R., CASLAKE M., BEDFORD D., ACHARYA J., ...More

CLINICAL CHEMISTRY, vol.51, no.1, pp.119-124, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1373/j.clinchem.2004.040121
  • Journal Name: CLINICAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.119-124
  • Inonu University Affiliated: No

Abstract

Background: Apolipoprotein E (apoE) is found in association with triglyceride-rich lipoproteins and is the ligand for the removal of these particles from the plasma. Genetic variations in exon 4 lead to three common gene variants: E2, E3, and E4.