N-Heterocyclic carbene-palladium catalysts for the direct arylation of pyrrole derivatives with aryl chlorides
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, vol.9, pp.303-312, 2013 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 9
- Publication Date: 2013
- Doi Number: 10.3762/bjoc.9.35
- Journal Name: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.303-312
- Keywords: aryl chlorides, atom-economy, C-H bond activation, C-H functionalization, carbenes, palladium, pyrroles, ORGANOMETALLIC CATALYSIS, HETEROAROMATIC-COMPOUNDS, METAL-COMPLEXES, BOND FORMATION, NHC LIGANDS, PHOSPHINES, BROMIDES, AMINATION, C-2
- Inonu University Affiliated: Yes
Abstract
New Pd-NHC complexes have been synthesized and employed for palladium-catalyzed direct arylation of pyrrole derivatives by using electron-deficient aryl chlorides as coupling partners. The desired coupling products were obtained in moderate to good yields by using 1 mol % of these air-stable palladium complexes. This is an advantage compared to the procedures employing air-sensitive phosphines, which have been previously shown to promote the coupling of aryl chlorides with heteroarenes.