Effects of Recombinant Activated Protein C Derived From Drotrecogin-Alpha on Bleomycin-Induced Pulmonary Fibrosis in Rats Compared with Methyl-Prednisolone

Yildiz K., Iraz M., ŞAMDANCI E., GÜREL E., KUKU İ., AYTEMUR Z. A., ...Daha Fazla

TURKISH THORACIC JOURNAL, cilt.14, sa.2, ss.48-52, 2013 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5152/ttd.2013.10
  • Dergi Adı: TURKISH THORACIC JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.48-52
  • Anahtar Kelimeler: Bleomycin, pulmonary fibrosis, recombinant activated protein C, methyl-prednisolone, rat
  • İnönü Üniversitesi Adresli: Evet

Özet

OBJECTIVE: In this study, we aimed to test the preventive effects of intraperitoneally administered drotrecogin alpha which is derived from activated protein C (APC), on bleomycin-induced pulmonary fibrosis in rats, and to compare the effects of APC with the effects of methyl-prednisolone, a traditional therapy.