Antioxidative effects of novel synthetic organoselenium compound in rat lung and kidney

TALAS Z. S., ÖZDEMİR İ., Yılmaz İ., GÖK Y.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, cilt.72, sa.3, ss.916-921, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.ecoenv.2007.11.012
  • Dergi Adı: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.916-921
  • Anahtar Kelimeler: DMBA, Kidney, Lung, Oxidative stress, Rat, Synthetic organoselenium compounds, SELENIUM SUPPLEMENTATION, SUPEROXIDE-DISMUTASE, CANCER PREVENTION, OXIDATIVE STRESS, EBSELEN, INHIBITION, PARAMETERS, TISSUE, DAMAGE, TRIAL
  • İnönü Üniversitesi Adresli: Evet

Özet

The effects of environmental chemicals, drugs, and physical agents on the developing lung and kidney are influenced by the state of development and maturation. Selenium is an essential element with physiological nonenzymatic antioxidant properties. Therefore, we undertook the present study to evaluate the antioxidant potential of the novel synthetic organoselenium compounds (Se I and Se II). In this study, adult female Wistar rats were treated with DMBA and the novel organoselenium compounds [1-isopropyl-3-methylbenzimidazole-2-selenone (Se I) and 1,3-di-p-methoxybenzylpyrimidine-2-selenone (Se II)] in the determined doses. The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)] parameters in rat lung and kidney were investigated. As a result, it was found that both Se I and Se II had provided the antioxidant effects against DMBA-induced oxidative stress in rat lung and kidney and lipid peroxidation had also been decreased by these organoselenium compounds. (c) 2007 Elsevier Inc. All rights reserved.