Evaluation of the Effects of Novel Nafimidone Derivatives on Thermal Hypoalgesia in Mice with Diabetic Neuropathy
BALKAN MEDICAL JOURNAL, vol.30, no.1, pp.94-98, 2013 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 30 Issue: 1
- Publication Date: 2013
- Doi Number: 10.5152/balkanmedj.2012.067
- Journal Name: BALKAN MEDICAL JOURNAL
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.94-98
- Inonu University Affiliated: Yes
Abstract
Objective: Diabetic neuropathy (DN) is a common complication in Diabetes Mellitus. The streptozotocin-induced diabetic rodent is the most commonly used animal model of diabetes and increased sodium channel expression and activity were revealed in this model. At this study, we evaluated the effect of three different nafimidone derivatives which have possible anticonvulsant activity on disorders of thermal pain sensation in diabetic mice.