Synthesis and antimicrobial studies of 1-methyl-2-dimethylaminoethyl-substituted benzimidazolium salts and N-heterocyclic carbene-silver complexes
JOURNAL OF COORDINATION CHEMISTRY, vol.65, no.3, pp.371-379, 2012 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 65 Issue: 3
- Publication Date: 2012
- Doi Number: 10.1080/00958972.2012.654469
- Journal Name: JOURNAL OF COORDINATION CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.371-379
- Keywords: N-heterocyclic carbene, Benzimidazolium salts, Silver, Antimicrobial, Medical inorganic chemistry, RING-OPENING POLYMERIZATION, C-H ACTIVATION, OLEFIN METATHESIS, SILVER(I)-CARBENE COMPLEXES, METAL-COMPLEXES, CATALYSTS, LIGANDS, PALLADIUM(II), EFFICIENT
- Inonu University Affiliated: Yes
Abstract
The synthesis and antimicrobial studies of 1-methyl-2-dimethylaminoethyl-substituted carbene precursors and silver complexes are reported. The carbene precursors (1a-d) have been prepared from 1-methyl-2-dimethylaminoethyl-substituted benzimidazole and various alkyl halides. The silver-NHC complexes (2a-d) were synthesized from the benzimidazolium salts and Ag2O in dichloromethane at room temperature. The new compounds were characterized by H-1 NMR, C-13 NMR, FT-IR, and elemental analyses. The new carbene precursors and Ag-complexes were tested for their in vitro antimicrobial activity against a variety of Gram-positive and Gram-negative bacteria, as well as for their antifungal activities against Candida albicans and Candida tropicalis.