Synthesis of N-heterocyclic carbene-based silver complexes and their antimicrobial properties against bacteria and fungi

KALOĞLU M., Kaloglu N., GÜNAL S., ÖZDEMİR İ.

JOURNAL OF COORDINATION CHEMISTRY, cilt.74, sa.17-20, ss.3031-3047, 2022 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 74 Sayı: 17-20
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/00958972.2021.2014457
  • Dergi Adı: JOURNAL OF COORDINATION CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Metadex
  • Sayfa Sayıları: ss.3031-3047
  • Anahtar Kelimeler: N-Heterocyclic carbene, benzimidazol-2-ylidene, silver, antimicrobial activity, metallodrugs, SILVER(I)-CARBENE COMPLEXES, MEDICINAL APPLICATIONS, DNA-BINDING, RESISTANCE, CATALYSTS, ARYLATION
  • İnönü Üniversitesi Adresli: Evet

Özet

N-Heterocyclic carbene-based silver complexes (Ag-NHCs) have been widely used as organometallic drug candidates in medicinal and pharmaceutical chemistry research due to their low toxicity. Due to the success of Ag-NHCs in biological applications, interest in the synthesis and applications of such compounds is increasing rapidly. Therefore, in this study, ten Ag-NHC complexes containing benzimidazol-2-ylidene ligand were synthesized and characterized by H-1 NMR, C-13 NMR, FT-IR spectroscopies and elemental analyses. The antimicrobial activity of Ag-NHCs was tested against some standard culture collections of Gram-negative, Gram-positive bacterial strains and fungal strains, which are the most frequently isolated among the society and hospital acquired infectious microorganisms as potential metallopharmaceutical agents. The Ag-NHC complexes showed effective antimicrobial activity against microorganisms with MIC values between 6.25 and 100 mu g/mL.