ACA, an inhibitor phospholipases A2 and transient receptor potential melastatin-2 channels, attenuates okadaic acid induced neurodegeneration in rats

Cakir M., DÜZOVA H., TEKİN S., Taslidere E., Kaya G. B., ÇİĞREMİŞ Y., ...Daha Fazla

LIFE SCIENCES, cilt.176, ss.10-20, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 176
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.lfs.2017.03.022
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.10-20
  • Anahtar Kelimeler: Okadaic acid, N-(p-amylcinnamoyl) anthranilic acid (ACA), Neurodegeneration, TRPM2 channel, Phospholipases A(2), Alzheimer's disease, SPATIAL MEMORY IMPAIRMENT, CENTRAL-NERVOUS-SYSTEM, ALZHEIMERS-DISEASE, INFLAMMATORY RESPONSES, TRPM2 CHANNELS, BRAIN, A(2), MODEL, DEATH, ACCUMULATION
  • İnönü Üniversitesi Adresli: Evet

Özet

Aim: In recent studies, it has been shown that the Transient Receptor Potential Melastatin-2 Channels (TRPM2) and Phospholipases A2 (PLA(2)) inhibitors may have a protective effect on neurons. This study was aimed to investigate the protective effect of TRPM2 and PLA(2) inhibitor N-(p-amylcinnamoyl) Anthranilic Acid (ACA) in a neurodegenerative model induced by Okadaic Acid (OKA).