ACA, an inhibitor phospholipases A2 and transient receptor potential melastatin-2 channels, attenuates okadaic acid induced neurodegeneration in rats

Cakir M., DÜZOVA H., TEKİN S., Taslidere E., Kaya G. B., ÇİĞREMİŞ Y., ...More

LIFE SCIENCES, vol.176, pp.10-20, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 176
  • Publication Date: 2017
  • Doi Number: 10.1016/j.lfs.2017.03.022
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.10-20
  • Keywords: Okadaic acid, N-(p-amylcinnamoyl) anthranilic acid (ACA), Neurodegeneration, TRPM2 channel, Phospholipases A(2), Alzheimer's disease, SPATIAL MEMORY IMPAIRMENT, CENTRAL-NERVOUS-SYSTEM, ALZHEIMERS-DISEASE, INFLAMMATORY RESPONSES, TRPM2 CHANNELS, BRAIN, A(2), MODEL, DEATH, ACCUMULATION
  • Inonu University Affiliated: Yes

Abstract

Aim: In recent studies, it has been shown that the Transient Receptor Potential Melastatin-2 Channels (TRPM2) and Phospholipases A2 (PLA(2)) inhibitors may have a protective effect on neurons. This study was aimed to investigate the protective effect of TRPM2 and PLA(2) inhibitor N-(p-amylcinnamoyl) Anthranilic Acid (ACA) in a neurodegenerative model induced by Okadaic Acid (OKA).