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Cakir M., DÜZOVA H., TEKİN S., Taslidere E., Kaya G. B., ÇİĞREMİŞ Y., ...More
LIFE SCIENCES, vol.176, pp.10-20, 2017 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
176
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Publication Date:
2017
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Doi Number:
10.1016/j.lfs.2017.03.022
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Journal Name:
LIFE SCIENCES
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Page Numbers:
pp.10-20
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Keywords:
Okadaic acid, N-(p-amylcinnamoyl) anthranilic acid (ACA), Neurodegeneration, TRPM2 channel, Phospholipases A(2), Alzheimer's disease, SPATIAL MEMORY IMPAIRMENT, CENTRAL-NERVOUS-SYSTEM, ALZHEIMERS-DISEASE, INFLAMMATORY RESPONSES, TRPM2 CHANNELS, BRAIN, A(2), MODEL, DEATH, ACCUMULATION
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Inonu University Affiliated:
Yes
Abstract
Aim: In recent studies, it has been shown that the Transient Receptor Potential Melastatin-2 Channels (TRPM2) and Phospholipases A2 (PLA(2)) inhibitors may have a protective effect on neurons. This study was aimed to investigate the protective effect of TRPM2 and PLA(2) inhibitor N-(p-amylcinnamoyl) Anthranilic Acid (ACA) in a neurodegenerative model induced by Okadaic Acid (OKA).