The therapeutic efficacy of dexpanthenol on sciatic nerve injury in a rat model


KORKMAZ M. F., PARLAKPINAR H., Erdem M. N., CEYLAN M. F., Ediz L., ŞAMDANCI E., ...Daha Fazla

BRITISH JOURNAL OF NEUROSURGERY, cilt.34, sa.4, ss.397-401, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/02688697.2020.1749984
  • Dergi Adı: BRITISH JOURNAL OF NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE, Violence & Abuse Abstracts
  • Sayfa Sayıları: ss.397-401
  • Anahtar Kelimeler: Bone mineral density, dexpanthenol, peripheral nerve trauma, static sciatic index, SPINAL-CORD-INJURY, FUNCTIONAL RECOVERY, CRUSH INJURY, BONE LOSS, DAMAGE
  • İnönü Üniversitesi Adresli: Evet

Özet

Objective: The aim of this study was to evaluate histopathological, functional and bone densitometry examinations of the beneficial effects of dexpanthenol (DEX) on nerve regeneration in a rat model of peripheral nerve crush injury. Methods: Thirty adult Sprague-Dawley rats were divided equally into three groups. A crush injury was simulated in all rats by clamping the right sciatic nerve for one minute. In group 1, one day before the surgical procedure, 500 mg/kg DEX administered via intraperitoneally (ip) was initiated and continued three times in a week during the experiment period as 28 days. In group 2, rats received a dose of 10 mg/kg DEX to investigate possible effects of DEX alone. Group 3 served as the control (sciatic nerve injury) and was not given any drugs. Results: Performance was significantly lower in group 3 compared to the drug treatment groups during the rotarod test (30 rpm and 40 rpm) (p < 0.05). After a while, the rats which were able to remain on the rod was significantly lower in group 3 during the acceleration test (p < 0.05). Hot plate latency test results in group 3 were significantly lower when compared to the other groups (p < 0.05). Conclusion: DEX appears to be useful as a supportive clinical agent for the treatment of pain and nerve damage.