The effect of lidocaine on TRPM 2,6,7 and 8 channels in liver ischemia / reperfusion model in rats

Bilecik T., Ozozan O. V., Coke H.

ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, cilt.11, sa.4, ss.319-324, 2020 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4328/acam.20075
  • Dergi Adı: ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.319-324
  • İnönü Üniversitesi Adresli: Evet

Özet

Aim: The transient receptor potential melastatin (TRPM) channel is subfamilies of the transient receptor potential (TRP) channels, cation permeable channels. Ischemia and reperfusion (I / R) injury is a phenomenon highlighting cellular damage of the liver caused by oxygen. Lidocaine is a local anesthetic that blocks sodium channels and suppresses mitochondrial functions of neutrophils. In this study, we purpose to investigate the effects of TRPM2/8 and TRPM6/7 expressions after lidocaine treatment in liver ischemia/reperfusion rat model.