Gold(I) Complexes of N-Heterocyclic Carbene Ligands Containing Benzimidazole: Synthesis and Antimicrobial Activity

ÖZDEMİR İ., TEMELLI N., GÜNAL S., DEMIR S.

MOLECULES, vol.15, no.4, pp.2203-2210, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 4
  • Publication Date: 2010
  • Doi Number: 10.3390/molecules15042203
  • Journal Name: MOLECULES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2203-2210
  • Keywords: gold, N-heterocyclic carbene, metallopharmaceutical agent, antimicrobial, benzimidazol-2-ylidene, AU(I)
  • Inonu University Affiliated: Yes

Abstract

Gold(I) N-heterocyclic carbene (NHC) complexes were obtained in good yields from the corresponding silver complexes by treatment with [AuCl(PPh3)] following the commonly used silver carbene transfer route. The silver complexes were synthesized from the benzimidazolium halide salts by the in situ reactions with Ag2O in dichloromethane as a solvent at room temperature. All gold complexes have been characterized by H-1-NMR, C-13-NMR and IR spectroscopy and elemental analysis. Au-NHC complexes were evaluated for their in vitro antimicrobial activity against a variety of Gram-positive and Gram-negative bacteria and fungal species.