Differences in platelet aggregometers to study platelet function and coagulation dysregulation in xenotransplantation

Isidan A., Chen A. M., Saglam K., YILMAZ S., Zhang W., Li P., ...Daha Fazla

XENOTRANSPLANTATION, cilt.28, sa.1, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 28 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1111/xen.12645
  • Dergi Adı: XENOTRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: impedance aggregometry, optical aggregometry, rotational thromboelastometry, thromboelastography, xenotransplantation, EX-VIVO MODEL, PROLONGS SURVIVAL, REFERENCE VALUES, TISSUE FACTOR, SWINE LUNGS, HUMAN BLOOD, IN-VITRO, PIG, AGGREGATION, THROMBOELASTOGRAPHY
  • İnönü Üniversitesi Adresli: Evet

Özet

Xenotransplantation (ie, cross-species transplantation) using genetically engineered pig organs could be a limitless source to solve the shortage of organs and tissues worldwide. However, despite prolonged survival in preclinical pig-to-nonhuman primate xenotransplantation trials, interspecies coagulation dysregulation remains to be overcome in order to achieve continuous long-term success. Different platelet aggregometry methods have been previously used to study the coagulation dysregulation with wild-type and genetically engineered pig cells, including the impact of possible treatment options. Among these methods, while thromboelastography and rotational thromboelastometry measure the change in viscoelasticity, optical aggregometry measures the change in opacity. Recently, impedance aggregometry has been used to measure changes in platelet aggregation in electrical conductance, providing more information to our understanding of coagulation dysregulation in xenotransplantation compared to previous methods. The present study reviews the merits and differences of the above-mentioned platelet aggregometers in xenotransplantation research.