Protective Effects of Apocynin on Cisplatin-induced Hepatotoxicity in Rats

CAGIN Y. F., ERDOĞAN M. A., Sahin N., PARLAKPINAR H., ATAYAN Y., POLAT A., ...Daha Fazla

ARCHIVES OF MEDICAL RESEARCH, cilt.46, sa.7, ss.517-526, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 7
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.arcmed.2015.08.005
  • Dergi Adı: ARCHIVES OF MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.517-526
  • Anahtar Kelimeler: Cisplatin, Apocynin, Hepatotoxicity, Oxidative stress, INDUCED OXIDATIVE STRESS, INDUCED NEPHROTOXICITY, NADPH OXIDASE, INDUCED LIVER, DAMAGE, APOPTOSIS, CURCUMIN, ACID, ERDOSTEINE, EXPRESSION
  • İnönü Üniversitesi Adresli: Evet

Özet

Background and Aims. Despite it being a highly potent antineoplastic drug, cisplatin has important toxic adverse effects limiting its use such as nephrotoxicity, neurotoxicity and ototoxicity. It is thought that cisplatin-induced hepatotoxicity is caused by oxidative stress resulting from increased reactive oxygen species (ROS). Apocynin (APO) exerts its antioxidant effect by reducing ROS production via inhibition of NADPH oxidase. The present study intended to demonstrate effects of cisplatin on hepatic pro-oxidant/antioxidant systems and to investigate protective effects of APO against cisplatin-induced hepatotoxicity.