Protective Effects of Apocynin on Cisplatin-induced Hepatotoxicity in Rats

CAGIN Y. F., ERDOĞAN M. A., Sahin N., PARLAKPINAR H., ATAYAN Y., POLAT A., ...More

ARCHIVES OF MEDICAL RESEARCH, vol.46, no.7, pp.517-526, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 7
  • Publication Date: 2015
  • Doi Number: 10.1016/j.arcmed.2015.08.005
  • Journal Name: ARCHIVES OF MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.517-526
  • Keywords: Cisplatin, Apocynin, Hepatotoxicity, Oxidative stress, INDUCED OXIDATIVE STRESS, INDUCED NEPHROTOXICITY, NADPH OXIDASE, INDUCED LIVER, DAMAGE, APOPTOSIS, CURCUMIN, ACID, ERDOSTEINE, EXPRESSION
  • Inonu University Affiliated: Yes

Abstract

Background and Aims. Despite it being a highly potent antineoplastic drug, cisplatin has important toxic adverse effects limiting its use such as nephrotoxicity, neurotoxicity and ototoxicity. It is thought that cisplatin-induced hepatotoxicity is caused by oxidative stress resulting from increased reactive oxygen species (ROS). Apocynin (APO) exerts its antioxidant effect by reducing ROS production via inhibition of NADPH oxidase. The present study intended to demonstrate effects of cisplatin on hepatic pro-oxidant/antioxidant systems and to investigate protective effects of APO against cisplatin-induced hepatotoxicity.