The protective effect of aminoguanidine on random pattern skin flap survival: An experimental study in rats

AYDOGAN H., GUERLEK A., PARLAKPINAR H., AYDOĞAN N., Acet A.

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, cilt.27, sa.1, ss.36-43, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 1
  • Basım Tarihi: 2007
  • Dergi Adı: TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.36-43
  • İnönü Üniversitesi Adresli: Evet

Özet

Objective: Distal flap necrosis resulting from ischemia is a serious problem, and increases the cost of treatment. Reactive oxygen radicals (ROS) play an important role in tissue injury and ischemia, and may lead to partial or complete flap necrosis. Aminoguanidine (AG), a potent antioxidant, prevents ROS formation and lipid peroxidation. Besides, AG inhibits inducible nitric oxide synthase (iNOS) leading to decreased generation of nitric oxide (NO).