CHANGES IN TYROSINE HYDROXYLASE ACTIVITY, ADRENOMEDULLIN (ADM) AND TOTAL RNA LEVELS BY TREATMENT OF ORGANOSELENIUM COMPOUNDS IN RAT HYPOTHALAMUS EXPOSED TO 7,12-DIMETHYLBENZANTHRACENE (DMBA)


ÖZDEMİR İ., TALAS Z. S., GÖK Y., ATEŞ B., Yılmaz İ.

FRESENIUS ENVIRONMENTAL BULLETIN, vol.19, no.4A, pp.664-668, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4A
  • Publication Date: 2010
  • Journal Name: FRESENIUS ENVIRONMENTAL BULLETIN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.664-668
  • Keywords: Tyrosine hydroxylase, adrenomedullin, hypothalamus, synthetic organoselenium compounds, DMBA, HEMATOLOGICAL PARAMETERS, HYPOTENSIVE PEPTIDE, GENE-EXPRESSION, SELENIUM, MODULATION, EXERCISE, STRESS, BRAIN, COLD, STEP
  • Inonu University Affiliated: Yes

Abstract

The effects of synthetic organoselenium compounds (Se I and Se II) on the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis as well as adrenomedullin (ADM) and total RNA levels were determined in the hypothalamus of adult rats exposed to DMBA (7,12-dimethylbenz[a]anthracene).