Ameliorative effects of aminoguanidine on rat aorta in Streptozotocin-induced diabetes and evaluation of alpha-SMA expression

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ELBE H., VARDI N., ORMAN D., TASLIDERE E., YILDIZ A.

ANATOLIAN JOURNAL OF CARDIOLOGY, vol.14, no.8, pp.679-684, 2014 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 14 Issue: 8
• Publication Date: 2014
• Doi Number: 10.5152/akd.2014.5047
• Journal Name: ANATOLIAN JOURNAL OF CARDIOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
• Page Numbers: pp.679-684
• Keywords: diabetes, aminoguanidine, alpha-smooth muscle actin, nitric oxide, aorta, rat, SMOOTH-MUSCLE-CELLS, INTIMA-MEDIA THICKNESS, OXIDATIVE STRESS, LIPID-PEROXIDATION, NITRIC-OXIDE, ATHEROSCLEROSIS, MARKER, GROWTH, PROTECTS, LESIONS
• Inonu University Affiliated: Yes

Abstract

Objective: Diabetes mellitus is one of the chronic metabolic diseases which is characterized by microvascular and macrovascular complications. This study was designed to investigate the improving the effects of amnioguanidine on aortic damage in a streptozotocin (STZ) induced diabetic rat model.