New derivatives of benzimidazole and their antimicrobial activity


CETINKAYA E., Alici B., Gok Y., DURMAZ R., Gunal S.

JOURNAL OF CHEMOTHERAPY, vol.11, no.2, pp.83-89, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 2
  • Publication Date: 1999
  • Doi Number: 10.1179/joc.1999.11.2.83
  • Journal Name: JOURNAL OF CHEMOTHERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.83-89
  • Keywords: antimicrobials, benzimidazole, benzothiazole, benzoxazole derivatives, CARBENE COMPLEXES
  • Inonu University Affiliated: Yes

Abstract

Azolium salts and neutral 2-aryl derivatives of benzimidazole, benzothiazole and benzoxazole were synthesized and compounds were identified by H-1 and C-13 NMR spectroscopy and microanalytical methods. In this work the salts I and the neutral compounds 2 were evaluated for their in vitro antimicrobial activity against standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Candida albicans and Candida tropicals.