Dexmedetomidine ameliorates TNBS-induced colitis by inducing immunomodulator effect


Kayhan G. , GÜL M. , KAYHAN B. , GEDIK E., ÖZGÜL Ü. , KURTOGLU E. L. , ...More

JOURNAL OF SURGICAL RESEARCH, vol.183, no.2, pp.733-741, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 183 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.1016/j.jss.2013.03.028
  • Title of Journal : JOURNAL OF SURGICAL RESEARCH
  • Page Numbers: pp.733-741

Abstract

Background: Since sedatives are often administered to immune-compromised and critically ill patients, our understanding of immunomodulation by sedation will be critical. Dexmedetomidine, a selective alpha(2)-adrenergic receptor agonist, is often used for sedation and analgesia especially in intensive care units. There are conflicting and little data concerning both the effect and the mechanism of dexmedetomidine on immune response. In our study, we aimed to investigate the effect of dexmedetomidine on immune system at two different doses (5 mu g.kg(-1) and 30 mu g.kg(-1)) during inflammatory bowel disease by using an experimental model, which resembles both systemic and local inflammation.