Synthesis, antioxidant and anti-microbial properties of two organoselenium compounds


TALAS Z. S., GÖK Y., ÖZDEMİR İ., ATEŞ B., GÜNAL S., YILMAZ İ.

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol.28, no.2, pp.611-616, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2015
  • Journal Name: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.611-616
  • Keywords: Synthetic organoselenium compounds, antioxidant activity, antimicrobial activity, SUBSTITUTED DERIVATIVES, SELENIUM
  • Inonu University Affiliated: Yes

Abstract

The aim of this study is synthesis of two different series of organoselenium compounds and available in vitro antioxidant and antimicrobial properties of thee synthetic compounds. The synthetic compounds were identified by H-1-NMR (300 MHz), C-13-NMR (75.5 MHz), FT-IR spectroscopic techniques and micro analysis. Antioxidant properties of two synthetic organoselenium compounds were determined by 1,1- dipheny1-2-picrylhydrazyl (DPPH) radical method, reducing power assay and beta-carotene bleaching method as in vitro. Antimicrobial effects of samples were assessed by the agar dilution procedure and using gram positive and gram-negative bacteria and yeast strains. Although 1,3-di-pmethoxybenzylpyrimidine-2-selenone showed better antiradical activity in DPPH test and higher protective activity on beta-carotene, 1-isopropyl-3-methylbenzimidazole-2-selenone was found to be better in reducing power and antimicrobial activity.