Methionine sulfoxide reduction and the aging process

Koc A., Gladyshev V. N.

BIOGERONTOLOGY: MECHANISMS AND INTERVENTIONS, cilt.1100, ss.383-386, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1100
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1196/annals.1395.042
  • Dergi Adı: BIOGERONTOLOGY: MECHANISMS AND INTERVENTIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.383-386
  • Anahtar Kelimeler: aging, ROS, methionine sulfoxide reductase, anaerobic, yeast life span, LIFE-SPAN, OXIDATION, MECHANISM
  • İnönü Üniversitesi Adresli: Evet

Özet

Aging has been described for multicellular and asymmetrically dividing organisms, but the mechanisms are poorly understood. Oxidation of proteins is considered to be one of the major factors that leads to aging. Oxidative damage to proteins results in the oxidation of certain amino acid residues, among which oxidation of sulfur-containing amino acids, methionine and cysteine, is notable because of the susceptibility of these residues to damage, and occurrence of repair mechanisms. Methionine sulfoxide reductases, MsrA and MsrB, are thioredoxin-dependent oxidoreductases that reduce oxidized forms of methionine, methionine sulfoxides, in a stereospecific manner. These enzymes are present in all cell. types and have shown to be regulating life spans in mammals, insects, and yeast. Here, their roles in modulating yeast life span are discussed.