The Effect of Beta Glucan on Cisplatin Ototoxicity

BAYINDIR T., Iraz M., Kelles M., Kaya S., TAN M., Filiz A., ...Daha Fazla

INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY, cilt.66, sa.2, ss.131-134, 2014 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 66 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1007/s12070-013-0623-0
  • Dergi Adı: INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.131-134
  • Anahtar Kelimeler: Ototoxicity, Cisplatin, Betaglucan, Otoacoustic emissions
  • İnönü Üniversitesi Adresli: Evet

Özet

This study was undertaken to investigate the effect of betaglucan in ameliorating cisplatin ototoxicity. Rats were divided into four groups: cisplatin (C), cisplatin plus beta glucan (CB), beta glucan (B), and control (K). Distortion product otoacoustic emissions were elicited in 0th, 1st, and 5th days. For the group C differences were observed at 8,003 and 9,515 Hz between 0th and 5th days' measurements. In the group CB there were differences at frequencies of 3,996, 4,757, 5,660, and 6,726 Hz between 0th and 5th days' measurements. For the group B there were significant recovery in some frequencies. The observation of significant deterioration in terms of hearing in the group treated with cisplatin plus betaglucan may be suggested that depended on the increase of permeability and tissue conductance into the inner ear which may be caused by betaglucan. Further long-term follow-up studies by using different doses may clarify this matter.