Novel benzimidazol-2-ylidene carbene precursors and their silver(I) complexes: Potential antimicrobial agents

KALOĞLU M., KALOGLU N., ÖZDEMİR İ., GÜNAL S., ÖZDEMİR İ.

BIOORGANIC & MEDICINAL CHEMISTRY, vol.24, no.16, pp.3649-3656, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 16
  • Publication Date: 2016
  • Doi Number: 10.1016/j.bmc.2016.06.004
  • Journal Name: BIOORGANIC & MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3649-3656
  • Keywords: N-Heterocyclic carbene, Silver(I)-NHC complexes, Benzimidazolium salts, Metallopharmaceuticals in vitro, antimicrobial activity, N-HETEROCYCLIC CARBENES, ESCHERICHIA-COLI, STRUCTURAL-CHARACTERIZATION, ORGANOMETALLIC CATALYSIS, RESPIRATORY-CHAIN, IONS, LIGANDS, BURNS, ANTIBACTERIAL, SULFADIAZINE
  • Inonu University Affiliated: Yes

Abstract

Novel benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) precursors, these NHC precursors were metallated with Ag2O in dichloromethane at room temperature to give novel silver (I)-NHC complexes. Structures of these benzimidazolium salts and silver(I)-NHC complexes were characterized on the basis of elemental analysis, H-1 NMR, C-13 NMR, IR and LC-MS spectroscopic techniques. A series of benzimidazolium salts and silver(I)-NHC complexes were tested against standard bacterial strains: Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and the fungal strains: Candida albicans and Candida tropicalis. The results showed that benzimidazolium salts inhibited the growth of all bacteria and fungi strains and all silver(I)-NHC complexes performed good activities against different microorganisms. (C) 2016 Elsevier Ltd. All rights reserved.