Synthesis and evaluation of novel N, N'-disubstituted benzimidazolium bromides salts as antitumor agents

KÜÇÜKBAY H., MUMCU A., TEKİN S., SANDAL S.

TURKISH JOURNAL OF CHEMISTRY, cilt.40, sa.3, ss.393-414, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3906/kim-1510-15
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.393-414
  • Anahtar Kelimeler: Benzimidazole derivatives, antitumor activity, A2780, PC-3, POTENTIAL ANTICANCER AGENTS, BIOLOGICAL EVALUATION, ANTIMICROBIAL ACTIVITY, ANTIFUNGAL ACTIVITY, DERIVATIVES, HYBRIDS, BENZOTHIAZOLE, INHIBITORS, ANTIBACTERIAL, IMIDAZOLE
  • İnönü Üniversitesi Adresli: Evet

Özet

Novel benzimidazolium bromides salts having (4-methoxyphenyl)ethyl, (phthalimide-2-yl)methyl, 4-nitrobenzyl, 2-phenylethyl, penthyl, or allyl groups were synthesized and their characterizations were conducted by H-1 and C-13 NMR and IR spectroscopic methods, and microanalysis. In vitro antitumor activities of the novel benzimidazole compounds (1-7) were determined by using ovarian (A2780) and prostate (PC-3) cancer cell lines. Antitumor properties of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MIT) assay. A time-dependent cell viability assay for the tested benzimidazole compounds was performed and the IC50 values of the compounds were calculated after treatment for 24 and 48 h. Our results indicate that the tested benzimidazole compounds show antitumor activity against A2780 and PC-3 cell lines (P < 0.05).