Mutations in GNA11 in Uveal Melanoma.

Van Raamsdonk C. D., Griewank K. G., Crosby M. B., Garrido M. C., Vemula S., Wiesner T., ...More

NEW ENGLAND JOURNAL OF MEDICINE, vol.363, no.23, pp.2191-2199, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 363 Issue: 23
  • Publication Date: 2010
  • Doi Number: 10.1056/nejmoa1000584
  • Journal Name: NEW ENGLAND JOURNAL OF MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2191-2199
  • Inonu University Affiliated: No

Abstract

Background: Uveal melanoma is the most common intraocular cancer. There are no effective therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of heterotrimeric G proteins, are found in 40% of uveal melanomas.