A study about excellent xanthine oxidase inhibitory effects of new pyridine salts


Yilmaz U., Noma S. A. A., Tok T. T., Sen B., GÖK Y., AKTAŞ A., ...Daha Fazla

MONATSHEFTE FUR CHEMIE, cilt.152, sa.10, ss.1251-1260, 2021 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 152 Sayı: 10
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s00706-021-02831-6
  • Dergi Adı: MONATSHEFTE FUR CHEMIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core
  • Sayfa Sayıları: ss.1251-1260
  • Anahtar Kelimeler: Pyridine salt, Xanthine oxidase, Molecular docking, Crystal structure, Enzyme inhibition, URIC-ACID, BIOLOGICAL EVALUATION, CRYSTAL-STRUCTURE, GOUT, ANTIBACTERIAL, HYPERURICEMIA, DERIVATIVES, MANAGEMENT, MECHANISM, DISCOVERY
  • İnönü Üniversitesi Adresli: Evet

Özet

A series of pyridine salts were synthesized containing vitamin B3 (niacin), isonicotinonitrile, and non-substituted pyridine fragment from reactions of 1,3-dibromopropane, 1,4-dibromobutane, and 4,4 '-bis(chloromethyl)-1,1 '-biphenyl reactants with pyridines. The builds of pyridine salts were identified by dint of IR, H-1, and C-13 NMR spectroscopic techniques, and CHN analyses. Therewithal, the build of a compound was assigned via the X-ray single-crystal diffraction method. 1,3-Bis(3-cyanopyridine-1-ium-1-yl)propane dibromide crystallizes in the orthorhombic space group Ccce, with half of the cation molecule and one bromide anion in the asymmetric unit. Enzyme inhibitory properties of pyridine compounds were tested on the activities of xanthine oxidase (XO) and determined in the range from 0.394 to 0.623 mu M. All of the compounds inhibited enzyme more effectively than allopurinol that which is a standard drug. In addition, docking calculations were applied to investigate the binding properties and interactions of pyridine salts towards XO. Graphic abstract