Proteomic Analysis of Liver Preservation Solutions Prior to Liver Transplantation

COSKUN A., BAYKAL A. T., Oztug M., KAZAN D., KAYA E., EMİROĞLU R., ...More

CURRENT PROTEOMICS, vol.16, no.2, pp.119-135, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.2174/1570164615666180905104543
  • Journal Name: CURRENT PROTEOMICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.119-135
  • Keywords: Liver, mass spectrometry, organ preservation solution, proteomics, liver transplantation, hypothermia, ISCHEMIA-REPERFUSION INJURY, GLUTATHIONE-S-TRANSFERASE, GRAFT FUNCTION, COLD ISCHEMIA, UW SOLUTION, EXPRESSION, ARGINASE, ENZYME, ALPHA, CELLS
  • Inonu University Affiliated: Yes

Abstract

Objective: Transplantation is the preferred treatment for patients with end-stage liver diseases. However, in clinical practice, functional preservation of the liver is a major concern before the transplantation. Although various protective solutions are used (in combination with hypothermia), the functional preservation time for liver is still limited to hours. We analyzed the preservation medium to detect the proteins released from the liver during storage period.