BIOLOGICAL ACTIVITY EVALUATION OF NOVEL N-HETEROCYCLIC CARBENE PRECURSORS

Akkoc, Senem; GÖK, YETKİN; Erdogan, Hulya; ALBAYRAK, SEVİL

doi:10.13040/ijpsr.0975-8232.8(1).262-67

BIOLOGICAL ACTIVITY EVALUATION OF NOVEL N-HETEROCYCLIC CARBENE PRECURSORS

Atıf İçin Kopyala

Akkoc S., GÖK Y., Erdogan H., ALBAYRAK S.

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, cilt.8, sa.1, ss.262-267, 2017 (Hakemli Dergi)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 8 Sayı: 1
Basım Tarihi: 2017
Doi Numarası: 10.13040/ijpsr.0975-8232.8(1).262-67
Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH
Sayfa Sayıları: ss.262-267
İnönü Üniversitesi Adresli: Evet

Özet

Five novel benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) precursors (1a-e). They were characterized by different techniques. The antimicrobial activities of these compounds were tested. The compounds showed moderate activity against three Gram (+) and seven Gram (-) bacteria in comparison to tetracycline, which was used as the standard antibiotic, whereas all the compounds (1a-e) showed no activity against the test yeast C. albicans.