The effects of novel synthetic organoselenium compounds on hematological parameters in DMBA-induced rats

SELAMOGLU Z., Ozdemir I., Atcs B., Goo Y., ORUN I., Yılmaz İ.

FRESENIUS ENVIRONMENTAL BULLETIN, vol.16, no.6, pp.596-600, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 6
  • Publication Date: 2007
  • Journal Name: FRESENIUS ENVIRONMENTAL BULLETIN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.596-600
  • Keywords: DMBA, hematological parameters, synthetic organoselenium compounds, OXIDATIVE STRESS, EBSELEN, ANTIOXIDANT, SELENIUM, INHIBITION, CHEMISTRY
  • Inonu University Affiliated: Yes

Abstract

Organic and inorganic selenium compounds are essential for humans and animals in reduction of oxidative stress. In the present study, the protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced rats were compared in hematological parameters. A statistically significant increase (P < 0.05) in total leukocyte count (WBC), as well as eosinophils, neutrophils, and monocyte values for rats exposed to DMBA was found. However, there was a statistically significant decrease in lymphocyte value (P < 0.05), and also in erythrocyte, hemoglobin and hematocrit values for rats exposed to DMBA, but MCV and MCH values (P < 0.05) significantly increased. With administration of novel synthetic organoselenium compounds (Se I and Se II), the effects of toxic DMBA on erythrocyte, hemoglobin and hematocrit values could be prevented statistically significant (P < 0.05). DMBA-induction in rats' hematological parameters was investigated, and the effects of Se I and Se II were outlined, evidencing their preservation role on hematological parameters and against DMBA toxicity.