Chlorogenic Acid Containing Bioinspired Polyurethanes: Biodegradable Medical Adhesive Materials

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ATEŞ B., KÖYTEPE S., KARAASLAN M. G., BALCIOGLU S., GULGEN S., DEMİRBİLEK M., ...More

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.64, no.12, pp.611-619, 2015 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 64 Issue: 12
• Publication Date: 2015
• Doi Number: 10.1080/00914037.2014.996710
• Journal Name: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.611-619
• Keywords: Biodegradable, bioinspired polyurethane, chlorogenic acid, tissue adhesive, CROSS-LINKING, TISSUE, POLYMERS, GLUE
• Inonu University Affiliated: Yes

Abstract

Highly adhesive bioinspired polyurethanes (PUs) based on the chlorogenic acid (CLA) were prepared from 4,4'-methylenebis (cyclohexyl isocyanate) (MCI) and polyethylene glycol 200 (PEG 200). The polyurethanes exhibited the lowest glass transition temperature (T-g), improved thermal stability and good adhesive properties. The highest adhesion strength was found as 373.3 +/- 47.5 kPa for 10% CLA containing PUs. The polyurethanes were observed to be biodegradable and were in the range of 19-24% for 8 weeks as depending on chlorogenic acid containing of PUs. As a result, prepared biocompatible-adhesive bioinspired polyurethanes are good candidates for medical applications as a tissue adhesive material.