Evaluation of reproductive and renal toxicity of varenicline in male rats


OĞUZ F. , BEYTUR A. , TAŞLIDERE E. , PARLAKPINAR H. , Oguz H. K. , Polat A., ...More

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol.22, no.12, pp.1392-1399, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 12
  • Publication Date: 2019
  • Doi Number: 10.22038/ijbms.2019.13986
  • Title of Journal : IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
  • Page Numbers: pp.1392-1399

Abstract

Objective(s): Varenicline is a selective partial agonist for the nicotinic acetylcholine receptor a4b2 subtype, which is widely used to treat smoking addiction. However, there is still no data about its potential toxic effects on tissues. In this study, we aimed to determine the varenicline-induced toxicity on reproductive and renal tissues in rats.