Caffeic acid phenethyl ester (CAPE) attenuates cerebral vasospasm after experimental subarachnoidal haemorrhage by increasing brain nitric oxide levels

ALADAG M., TURKOZ Y., OZCAN C., SAHNA E., Parlakpinar H., AKPOLAT N., ...More

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, vol.24, no.1, pp.9-14, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.1016/j.ijdevneu.2005.12.002
  • Journal Name: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.9-14
  • Keywords: rat, SAH, vasospasm, CAPE, MDA, GSH, NO, CHELATING AGENT DEFEROXAMINE, KINASE-C ACTIVATION, SUPEROXIDE-DISMUTASE, LIPID-PEROXIDATION, REPERFUSION INJURY, PROPOLIS EXTRACT, ARACHIDONIC-ACID, RAT MODEL, MONKEYS, CELLS
  • Inonu University Affiliated: Yes

Abstract

Background: Cerebral vasospasm, a medical complication of aneurysmal subarachnoid hemorrhage (SAH), is associated with high morbidity and mortality rates, even after the aneurysm has been secured surgically or endovascularly. Evidence accumulated during the last decade suggest that scavenging a vasodilator, nitric oxide (NO), by superoxide anions (O-2(-)), and activating a strong vasoconstructor, protein kinase C (PKC), are the two most important mechanisms in the pathogenesis of vasospasm. Our aim in this study was to determine whether caffeic acid phenethyl ester (CAPE), a non-toxic oxygen free radical scavenger, prevents vasospasm in an experimental rat model of SAH.