Effects of pinealectomy and exogenous melatonin on serum leptin levels in male rat

CANPOLAT S., Sandal S., YILMAZ B., YASAR A., KUTLU S., BAYDAS G., ...Daha Fazla

EUROPEAN JOURNAL OF PHARMACOLOGY, cilt.428, sa.1, ss.145-148, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 428 Sayı: 1
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0014-2999(01)01230-4
  • Dergi Adı: EUROPEAN JOURNAL OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.145-148
  • Anahtar Kelimeler: leptin, melatonin, pinealectomy, (rat), PLASMA LEPTIN, SECRETION, FAT, HORMONE, INSULIN, GLAND
  • İnönü Üniversitesi Adresli: Hayır

Özet

The effects of pinealectomy and exogenous melatonin (N-acetyl-5-methoxytryptamine) on serum leptin levels were investigated in rats. Exogenous administration of melatonin to intact rats resulted in significant decreases in serum leptin levels (P < 0.05) compared to those of the intact control group. Serum leptin levels were significantly elevated in the pinealectomised rats in comparison to the sham-pinealectomised animals (P < 0.001) and were significantly suppressed by exogenous administration of melatonin compared to those of non-treated pinealectomised rats ( P < 0.001). Hormone concentrations in the melatonin-treated pinealectomised group were found to be similar to those seen in the sham-pinealectomised group. These results suggest that pineal gland has an effect on leptin release. (C) 2001 Elsevier Science B.V. All rights reserved.