Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury
ARCHIVES OF MEDICAL SCIENCE, vol.15, no.2, pp.467-474, 2019 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 15 Issue: 2
- Publication Date: 2019
- Doi Number: 10.5114/aoms.2017.72550
- Journal Name: ARCHIVES OF MEDICAL SCIENCE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.467-474
- Keywords: brain injury, global cerebral ischemia, sodium channels, neuroprotection, GLUTATHIONE-PEROXIDASE-ACTIVITY, CEREBRAL-ISCHEMIA, CASPASE ACTIVATION, OXIDATIVE STRESS, CELL-DEATH, MODEL, MECHANISMS, APOPTOSIS, OXYGEN, REPERFUSION
- Inonu University Affiliated: Yes
Abstract
Introduction: RS100642, a mexiletine analogue, is a novel sodium channel blocker with neuroprotective and antioxidant activities. The protectivity of RS100642, which has been shown against focal cerebral ischemia, was investigated in global cerebral ischemia in this study.