Protective Effect of Quercetin Against Oxidative Stressinduced Toxicity Associated With Doxorubicin and Cyclophosphamide in Rat Kidney and Liver Tissue

KOCAHAN S., DOĞAN Z., Erdemli E., TAŞKIN E.

IRANIAN JOURNAL OF KIDNEY DISEASES, cilt.11, sa.2, ss.124-131, 2017 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 2
  • Basım Tarihi: 2017
  • Dergi Adı: IRANIAN JOURNAL OF KIDNEY DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.124-131
  • Anahtar Kelimeler: cyclophosphamide, doxorubicin, quercetin, oxidative stress, liver, kidney, LIPID-PEROXIDATION, DNA-DAMAGE, STRESS, CARDIOTOXICITY, INHIBITION, APOPTOSIS, CELLS, HEART
  • İnönü Üniversitesi Adresli: Hayır

Özet

Introduction. Doxorubicin and cyclophosphamide are widely used anticancer drugs with substantial toxicity in noncancerous tissue resulting from oxidative damage. Quercetin is a potent antioxidant compound. We hypothesized that quercetin administration would ameliorate the toxic effects of doxorubicin and cyclophosphamide prior to pregnancy.