Biodegradable non-aromatic adhesive polyurethanes based on disaccharides for medical applications

ATEŞ B., KÖYTEPE S., KARAASLAN M. G., BALCIOGLU S., GULGEN S.

INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES, vol.49, pp.90-96, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 49
  • Publication Date: 2014
  • Doi Number: 10.1016/j.ijadhadh.2013.12.012
  • Journal Name: INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.90-96
  • Keywords: Polyurethane, Novel adhesives, Bioadhesive, OIL-BASED POLYURETHANE, CASTOR-OIL, WATERBORNE POLYURETHANE, SOY-DREG, POLYESTER, STRENGTH, BLENDS
  • Inonu University Affiliated: Yes

Abstract

This work addresses synthesis, characterization, adhesive properties, protein adsorption and in vitro biodegradation of non-aromatic polyurethanes (NPUs). The following reactants were used in the syntheses of polyurethanes (PUs): non-aromatic 4,4'-Methylenebis(cyclohexyl isocyanate) (MCI), disaccharides (maltose and sucrose) and polyethylene glycol 200 (PEG 200). The NPUs exhibited low glass transition temperature (T-g) and good thermal stability. The dynamic contact angles on NPUs were influenced by the ratios of PEG 200-disaccharide monomer and the hard segment of the NPUs. The highest adhesion strength in whole polyurethanes was found as 307.6 +/- 50.1 kPa for 15% sucrose containing polyurethane. Protein adsorptions of polyurethane films were measured as average 10 pg Bovine Serum Albumin (BSA)/cm(2) and 5 mu g fibrinogen/cm(2) for maltose, and 15 mu g BSA/cm(2) and 5 mu g fibrinogen/cm(2) for sucrose. Biodegradability ratios of NPUs were in the range of 15-35% for 8 weeks depending on the disaccharides containing NPUs. (C) 2013 Elsevier Ltd. All rights reserved.