Molsidomine Prevents Cisplatin-induced Hepatotoxicity

BENTLİ R., PARLAKPINAR H., POLAT A., ŞAMDANCI E., SARIHAN M. E., SAGIR M.

ARCHIVES OF MEDICAL RESEARCH, vol.44, no.7, pp.521-528, 2013 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 7
  • Publication Date: 2013
  • Doi Number: 10.1016/j.arcmed.2013.09.013
  • Journal Name: ARCHIVES OF MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.521-528
  • Keywords: Cisplatin, Molsidomine, Liver, Oxidative stress, OXIDE DONOR MOLSIDOMINE, ISCHEMIA-REPERFUSION INJURY, NITRIC-OXIDE, INDUCED NEPHROTOXICITY, HEPATOCYTE APOPTOSIS, MYOCARDIAL-ISCHEMIA, OXIDATIVE STRESS, LIVER-DAMAGE, MELATONIN, PROTECTS
  • Inonu University Affiliated: Yes

Abstract

Background and Aims. Despite its beneficial effects, cisplatin has considerable nephrotoxic, ototoxic, neurotoxic and hepatotoxic side effects. It has been documented that reactive oxygen radical species are involved with the pathophysiology of cisplatin-induced hepatotoxicity. Molsidomine (MOL) can exert antioxidant and anti-inflammatory effects. Therefore, the current study was planned to determine the effects of cisplatin on the liver oxidant/antioxidant system and the possible protective effects of (MOL) on liver toxicity.