Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats

Parlakpinar H., Tasdemir S., POLAT A., BAY-KARABULUT A., Vardi N., UCAR M., ...More

TOXICOLOGY, vol.207, no.2, pp.169-177, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 207 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1016/j.tox.2004.08.024
  • Journal Name: TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.169-177
  • Keywords: caffeic acid phenethyl ester, gentamicin, reactive oxygen radicals, renal toxicity, rat, CISPLATIN-INDUCED NEPHROTOXICITY, INDUCED OXIDATIVE STRESS, LIPID-PEROXIDATION, REPERFUSION INJURY, IN-VITRO, PREVENTS, MELATONIN, NECROSIS, ANALOGS
  • Inonu University Affiliated: Yes

Abstract

The toxicity of gentamicin (GEN) in the kidney seems to relate to the generation of reactive oxygen species (ROS). Caffeic acid phenethyl ester (CAPE) has been demonstrated to have antioxidant, free radical scavenger and anti-inflammatory effects. It has been proposed that antioxidant maintain the concentration of reduced glutathione (GSH) may restore the cellular defense mechanisms and block lipid peroxidation thus protect against the toxicity of wide variety of nephrotoxic chemicals. We investigated the effects of CAPE on GEN-induced changes in renal malondialdehyde (MDA), a lipid peroxidation product, nitric oxide (NO) generation, superoxide dismutase (SOD), catalase (CAT) activities, GSH content, blood urea nitrogen (BUN) and serum creatinine (Cr) levels. Morphological changes in the kidney were also examined.