The Ameliorate Effects of Nerolidol on Thioacetamide-induced Oxidative Damage in Heart and Kidney Tissue

BAŞAK TÜRKMEN N., YÜCE H., TAŞLIDERE A., ŞAHİN Y., ÇİFTÇİ O.

Turk J Pharm Sci, cilt.19, sa.1, ss.1-8, 2022 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.4274/tjps.galenos.2021.30806
  • Dergi Adı: Turk J Pharm Sci
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1-8
  • Anahtar Kelimeler: Nerolidol, thioacetamide, lipid peroxidation, nephrotoxicity, cardiotoxicity, ESSENTIAL OIL, CHEMICAL-COMPOSITION, ANTIOXIDANT, INJURY, NEPHROTOXICITY, ACTIVATION, STRESS, LEAVES
  • İnönü Üniversitesi Adresli: Evet

Özet

Objectives: Thioacetamide (TAA) is an organosulfur, white crystalline compound having liver injury. However, it shows toxic effects on many organs. The reverts the oxidative stress created by TAA on the heart and kidney, and decreased lipid peroxide peroxidation back with antioxidant-properties nerolidol (NRL). This study hypothesized that NRL treatment a potential ameliorate nephrotoxicity and cardiotoxicity caused by TAA.