In vitro antimicrobial studies of naphthalen-1-ylmethyl substituted silver N-heterocyclic carbene complexes


GÖK Y., Akkoc S., Celikal O. O., ÖZDEMİR İ., GÜNAL S.

ARABIAN JOURNAL OF CHEMISTRY, cilt.12, sa.8, ss.2513-2518, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 8
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.arabjc.2015.04.019
  • Dergi Adı: ARABIAN JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2513-2518
  • Anahtar Kelimeler: Benzimidazol-2-ylidene, N-Heterocyclic carbene, Silver complex, Antibacterial activity, Antifungal activity, C-H ACTIVATION, NHC-COMPLEXES, BENZIMIDAZOLIUM SALTS, CATALYTIC-ACTIVITIES, CRYSTAL-STRUCTURES, METAL-COMPLEXES, MIZOROKI-HECK, ANTIBACTERIAL, PALLADIUM, PRECURSORS
  • İnönü Üniversitesi Adresli: Evet

Özet

Seven novel naphthalen-1-ylmethyl substituted silver N-heterocyclic carbene (Ag-NHC) complexes (1-7) were synthesized by the interaction of benzimidazolium salts with silver carbonate in dry dichloromethane at room temperature and characterized by means of spectroscopic methods and elemental analysis techniques. The Ag-NHC compounds were tested for their in vitro antibacterial and antifungal activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Candida albicans and Candida tropicalis and showed high antimicrobial activities. The synthesized complexes, in particular, demonstrated better results against both fungi and gram-positive bacteria. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of King Saud University.