Novel benzimidazolium salts and their silver(I)-N-heterocyclic carbene complexes: synthesis, characterization and their biological properties
Journal of Coordination Chemistry, vol.76, no.1, pp.120-133, 2023 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 76 Issue: 1
- Publication Date: 2023
- Doi Number: 10.1080/00958972.2022.2164191
- Journal Name: Journal of Coordination Chemistry
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Metadex
- Page Numbers: pp.120-133
- Keywords: antimicrobial and antitumor activities, benzimidazolium salts, morpholinoethyl, N-Heterocyclic carbene, silver(I)-NHC complexes
- Open Archive Collection: AVESIS Open Access Collection
- Inonu University Affiliated: Yes
Abstract
This study was conducted to synthesize and characterize 1,3-dialkyl-5,6-dimethyl-benzimidazolium salts and their silver complexes. Four novel silver(I)-N-heterocyclic carbene complexes were synthesized and characterized by mass analyses, FT-IR and NMR spectroscopy. The biological capacity of the synthesized compounds was evaluated in vitro for their antimicrobial and antitumor activities. The minimum inhibitory concentration (MIC) of the 1,3-dialkyl-5,6-dimethyl-benzimidazolium salts and their complexes was determined for E. coli, P. aeruginosa, S. aureus, C. glabrata and C. albicans in vitro through BMD (Broth Microdilution). The results indicated that silver(I)-NHC complexes exhibit antimicrobial activity. In particular, complex 3c presented a significant broad-spectrum antimicrobial activity. The anticancer properties of the synthesized compounds were evaluated against MCF-7, HCT116, SH-SY5Y and BEAS-2B cell lines. Anticancer activity measurements were carried out according to the Alamar Blue assay. Efficacy was established by comparison of the salts and silver compounds with cisplatin.