Protective and therapeutic effects of molsidomine on radiation induced neural injury in rats

DURAK M. A., PARLAKPINAR H., POLAT A., VARDI N., EKICI K., UÇAR M., ...Daha Fazla

BIOTECHNIC & HISTOCHEMISTRY, cilt.92, sa.1, ss.68-77, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 92 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/10520295.2016.1271454
  • Dergi Adı: BIOTECHNIC & HISTOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.68-77
  • Anahtar Kelimeler: molsidomine, neural damage, oxidative stress, radiotherapy, rat, INDUCED OXIDATIVE STRESS, WHOLE-BRAIN IRRADIATION, NITRIC-OXIDE, COGNITIVE IMPAIRMENT, DAMAGE, CYTOTOXICITY, ENHANCEMENT, MECHANISM, BIOLOGY, TISSUE
  • İnönü Üniversitesi Adresli: Evet

Özet

We investigated the protective and therapeutic effects of molsidomine (MOL) in a rat model of whole brain radiotherapy (RT). Forty female rats were divided into five groups of eight: group 1, control; group 2, 15 Gy single dose RT (RT); group 3, 4 mg/kg MOL treated for 5 days (MOL); group 4, 4 mg/kg MOL for 5 days, 10 days after RT treatment (RT + MOL); group 5, 4 mg/kg MOL treatment for 5 days before RT treatment and for 5 days after RT treatment (MOL + RT). All rats were sacrificed on day 16. Neurodegenerative changes in the brain and tissue levels of oxidants and antioxidants were evaluated. The oxidative parameters were increased and antioxidant status was decreased in group RT compared to groups MOL + RT and RT + MOL. Histopathological examination showed that treatment with MOL after RT application and treatment with MOL before RT treatment decreased neuronal degeneration. No difference in neuronal appearance was found between groups RT + MOL and MOL + RT. MOL treatment protected the nervous system of rats and may be a treatment option for preventing RT induced neural injury.