In the history of Islamic thought, there are two fundamental approaches that conflict with each other and that try to expound the formation of literature of prophetic medicine, one of which with prophethood (revelation) and the other of which with the reason (human effort). The fundamental question that would shed light on the background of both approaches is the question of how in the historical process the formation of the literature of prophetic medicine took place. Therefore, the question of how this literature emerged and developed, and what kind of concerns and thoughts lay behind it is a crucial question and problem. The principal aim of this study is to seek an answer to this question, to expose, analyze and discuss possible views in this context. The literature prophetic medicine appears to have been created based on various reasons as religious, mystical, historical, cultural and medical. In the historical process, these reasons were forgotten, acquired a certain sanctity and religious validity in time, and were considered as a prerequisite of prophethood.