The role of the eNOS G894T and T-786C gene polymorphism in the development of ascites in cirrhosis

YILDIRIM O., YIGIT A., SEÇKİN Y., YEŞİLADA E., GULBAY G., CAGIN Y. F., ...Daha Fazla

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.20, sa.22, ss.4725-4730, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 22
  • Basım Tarihi: 2016
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.4725-4730
  • Anahtar Kelimeler: Cirrhosis, Nitric oxide, Polymorphism, eNOS gene polymorphism, Ascites, OXIDE SYNTHASE GENE, NITRIC-OXIDE, HYPERDYNAMIC CIRCULATION, PORTAL-HYPERTENSION, PLASMA, LIVER, ADRENOMEDULLIN, MECHANISMS
  • İnönü Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Increased nitric oxide (NO) production in cirrhotic patients causes splanchnic vasodilation, leading to the development of the hyperdynamic circulatory syndrome. One factor that influences plasma NO concentration is eNOS gene polymorphism; consequently, the aim of this study was to investigate whether the eNOS gene G894T and T-786C polymorphisms play any role in the development of ascites in such patients.