New coumarin derivatives as carbonic anhydrase inhibitors

Karataş M. O., Alıcı B., Çakır Ü., Cetinkaya E., Demir D., Ergün A., ...Daha Fazla

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, cilt.42, sa.3, ss.192-198, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3109/21691401.2013.794352
  • Dergi Adı: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.192-198
  • Anahtar Kelimeler: benzimidazolium, carbonic anhydrase, coumarin, imidazolium, inhibition, AROMATIC/HETEROCYCLIC SULFONAMIDES, THERAPEUTIC APPLICATIONS, ERYTHROCYTE, TARGET, IX, PURIFICATION, BINDING, CLONING, PHENOL, SITE
  • İnönü Üniversitesi Adresli: Evet

Özet

In the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition effects of the derivatives on human carbonic anhydrases (hCA I and hCA II) were investigated as in vitro. Structures of these coumarins were confirmed by FT-IR, (1)H NMR, (13)C NMR and LC-MS analyses. Structure activity relationship study showed that 3d (IC50: 79 mu m M for hCA I and 88 m M for hCA II) performed higher inhibitory activity than others.