Favourable effect of beta-glucan treatment against cisplatin-induced reproductive system damage in male rats

KAYA K., ÇİFTÇİ O., AYDIN M., Cetin A., BAŞAK TÜRKMEN N.

ANDROLOGIA, cilt.51, sa.9, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 9
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1111/and.13342
  • Dergi Adı: ANDROLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: cisplatin, oxidative stress, spermiotoxicity, testicular damage, beta-glucan, OXIDATIVE ORGAN INJURY, TESTICULAR DAMAGE, FISH-OIL, STRESS, ANTIOXIDANT, LIVER, SERUM, ASSAY
  • İnönü Üniversitesi Adresli: Evet

Özet

The aim of this study was to investigate the potential beneficial effects of beta-glucan treatment against oxidative, histological and spermatological damage caused by cisplatin on the male reproductive system. Twenty-eight Sprague Dawley male rats were used in the study. The rats were randomly divided into four equal-sized groups: a control group, cisplatin group (7 mg/kg in a single-dose cisplatin administered intraperitoneally), beta-glucan group (beta-glucan given at a dose of 50 mg kg(-1) d(-1) for 14 day) and a cisplatin plus beta-glucan group (cisplatin and beta-glucan administered together at the same dose). Cisplatin administration induced an increase in the level of thiobarbituric acid-reactive substances, a lipid peroxidation indicator. It induced a decrease in enzymatic (superoxide dismutase, catalase and glutathione peroxidase) activities and nonenzymatic (reduced glutathione) antioxidant levels. In addition, cisplatin caused both histological and spermatological damage, as shown by a decrease in sperm motility and epididymal sperm concentrations and an increase in abnormal sperm rates. The beta-glucan treatment improved cisplatin-induced oxidative, histological and spermatological damage. This study revealed that beta-glucan treatment provided prevention against male reproductive system damage caused by cisplatin. These preventative effects were likely due to its antioxidant properties.